What is IGF-1 LR3?
IGF1-LR3 is a modified version of insulin-like growth factor-1. The full name of the peptide is insulin-like growth factor-1 long arginine 3. All IGF-1 derivatives play prominent roles in cell division, cell proliferation, and cell-to-cell communication. Though it has similar effects, IGF-1 LR3 does not adhere to IGF binding proteins as strongly as IGF-1. This results in IGF1-LR3 remaining in the bloodstream 120 times longer than IGF-1. IGF1-LR3 gains its prolonged half-life as a result of its structural changes.
IGF-1 LR3 Structure
Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.
Molecular Formula: C400H625N111O115S9
Molecular Weight: 9117.5 g/mol
CAS Number: 946870-92-4
source: PubChem
IGF-1 LR3 Research
IGF-1 LR3 & Cell Division
Like IGF-1, IGF1-LR3 is a potent stimulus for cell division and proliferation.
Its primary effects are on connective tissues like muscle and bone, but it also promotes cell division in liver, kidney, nerve, skin, lung, and blood tissues.
IGF-1 causes cells to mature, in other words, so that they can carry out their specialized functions, Unlike IGF-1, IGF1-LR3 remains in the bloodstream for long periods of time, This property makes IGF1-LR3 a much more potent molecule. A dose of IGF1-LR3 provides approximately three times as much cell activation as a similar dose of IGF-1.
IGF-1 promote cell division and proliferation (hyperplasia). In the case of muscle, for instance, IGF1-LR3 does not cause muscle cells to get larger, but it does increase total numbers of muscle cells.
IGF-1 LR3 & Fat Metabolism & Diabetes
IGF1-LR3 boosts fat metabolism in an indirect manner by binding to both the IGF-1R receptor and the insulin receptor. These actions increase glucose uptake from the blood by muscle, nerve, and liver cells. This results in an overall decrease in blood sugar levels, which then triggers adipose tissue as well as the liver to begin breaking down glycogen and triglycerides. Overall, this produces a net decrease in adipose tissue and a net energy consumption (i.e. net catabolism).
Given its role in reducing blood sugar levels, it should come as no surprise that IGF1-LR3 reduces insulin levels as well as the need for exogenous insulin in diabetes. In most cases, this translates into a 10% decrease in insulin requirements to maintain the same blood sugar levels. This fact may help scientists understand how to decrease insulin doses in individuals who have decreased insulin sensitivity and may even offer insight into preventing type 2 diabetes in the first place.
IGF-1 LR3 Peptide & Impairs Myostatin
Myostatin (a.k.a. growth differentiation factor 8) is a muscle protein that primarily inhibits the growth and differentiation of muscle cells. While this function is important to prevent unregulated hypertrophy and ensure proper healing following injury, there are times when inhibiting myostatin could be of benefit. The ability to stop myostatin from functioning could be useful in conditions like Duchenne muscle dystrophy (DMD) or in people who suffer muscle loss during prolonged immobility. In these cases, inhibiting this natural enzyme could help to slow muscle breakdown, maintain strength, and stave off morbidity.
IGF1-LR3 Peptide Longevity Research
IGF1-LR3 promotes tissue repair and maintenance throughout the body, making it a protective molecule against cell damage and the effects of aging, indicating that IGF1-LR3 may be effective solution for reducing the effects of cellular aging. preventing progression of a wide range of conditions such as dementia, muscle atrophy, and kidney disease. This research reveals that IGF-1 administration can prolong life and reduce disability
Glucocorticoid Signaling
Glucocorticoids, secreted primarily by the adrenal glands, are important clinical drugs used to control pain, reducing inflammation in autoimmune diseases, neurological injury, cancer, and more, Glucocorticoids have a number of undesirable side effects; muscle wasting, fat gain, and deterioration connected with bone density. There is some interest in implementing IGF1-LR3 to reduce the side effects ofGlucocorticoids,thus allow for more beneficial therapy
Dosage | 1mg (0.1mg x 10 Vials), 10mg (1mg x 10 Vials) |
---|
Related Products
Melanotan 2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone. Developed in the 1980s, Melanotan 2 has been shown to increase sexual arousal, reduce compulsive/addictive behavior, curb hunger, and promote lean body mass. Research has shown the peptide to stimulate melanocytes therefore producing increased skin pigmentation and may help to combat autism when used during early childhood development.
All Peptides are shipped non labeled
Epithalon (Epitalon) is a synthetic derivative of Epithalamin and a potential modulator of telomerase, the enzyme that maintains and protects the telomere caps at the ends of chromosomes (strands of DNA). Research suggests that Epithalon induces telomere elongation and may fight off the effects of aging as a result.
All Peptides are shipped non labeled
AOD-9604 is a modified version of the hGH fragment 176-191 peptide (contains a di-sulfide bridge) and thus a derivative of human growth hormone (hGH). Originally developed as a lipolytic (fat burning) compound, AOD9604 has shown benefit in studies of heart disease, osteoarthritis/cartilage repair, and metabolic syndrome. AOD9604 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis in animal studies.
All Peptides are shipped non labeled
Melanotan (MT-1) It is used clinically, to prevent sun-related skin damage (i.e. phototoxicity) from occurring in people suffering from erythropoietic protoporphyria. Though initially developed as a sunless tanning agent, melanotan 1 has been found to have a number of physiologic effects on blood pressure, feeding behavior, central nervous system function, and more.
100mg Kit
10mg X 10 Vials
All Peptides are shipped non labeled
Oxytocin, a natural protein hormone, plays important roles in sexual reproduction, childbirth, bonding between mother and child during breast feeding and wound healing. New research suggests that it may boost cognitive performance, reduce cardiovascular risk, and offset the effects of diabetes.
20mg Kit
2mg x 10 vials
All Peptides are shipped non labeled
Ipamorelin is a pentapeptide, meaning that its structure is comprised of five amino acids. It is a secretagogue, and is considered to be an agonist, meaning that it possesses the ability to bind certain receptors of a cell and provokes a cellular response. Ipamorelin’s operational mechanics enables the peptide to stimulate the production of pituitary gland-based expression of secretions related to growth amongst animal test subjects. At the same time, the presence of the peptide has been shown to inhibit the production of a secretion known as somatostatin. Additionally, it has been determined that Ipamorelin has the ability to boost the production of IGF-1, or Insulin-like Growth Factor 1. Its presence plays a key role in the overall growth and repair of muscular and skeletal tissue.
All Peptides are shipped non labeled
ACE-031 is a synthetic protein made up of activin receptor type IIB and the immunoglobulin G1-Fc (IgG1-Fc). It binds to myostatin and related proteins within muscle, rendering them inactive. Research shows it to be useful in stabilizing muscle mass and strength in both primary muscle-wasting disorders and neuromuscular conditions
10mg Kit
1mg X 10 Vials
All Peptides are shipped non labeled
Available on backorder
All Peptides are shipped non labeled
Hexarelin is a synthetic analogue of ghrelin that shows benefit in heart disease and cardiac ischemia, protecting the heart following heart attack. Research has shown that Hexarelin also protects skeletal muscle against wasting and improves cholesterol and triglyceride levels.
All Peptides are shipped non labeled
Categories
Tags
- 100iu
- Anastrazole
- anti aging
- anti wrinkles
- Arimidex
- Bodybuilding
- cjc
- cjc1295
- cjc 1295
- Clomid
- cycle
- dianbol
- fat loss
- genotropin
- gh
- ghrp
- gnrh
- growth hormone
- hgh
- human growth
- human growth hormone
- hygetropin
- igf
- igf-1
- jenotropin
- kingotropin
- kit
- methanabol
- methandione
- mgf
- nordictropin
- norditropin
- orals
- pct
- peptide
- peptides
- primo
- Primobolan
- roid
- roids
- Sarms
- somatropin
- steroid
- steroids
- testosterone