Tesamorelin, Ipamorelin (Blend)

Tesamorelin

Tesamorelin is a growth hormone releasing hormone analog that has been shown to increase IGF-1 levels in men by an average of 181 micrograms/liter. It binds and stimulates human GHRH receptors with similar potency as endogenous GHRH. It has a host of other benefits including nootropic effects and reducing triglycerides. Tesamorelin research has subsequently been shown to decrease carotid intima media thickness (cIMT), visceral adipose tissue (VAT), and C-reactive proteins (CRP) in a recent study. It has not been shown to significantly affect other pituitary hormones and their respective mechanisms in the body. Additionally, studies have shown it to improve cognitive function for healthy older adults and also for people with mild cognitive impairment who are at an increased risk of progressing to Alzheimer’s disease.

Ipamorelin

Ipamorelin is a selective GH-Secretagogue and ghrelin receptor agonist. The potency of ghrelin stimulation can be compared to GHRP6 with less appetite stimulation properties. However, unlike other GH-Secretagogues this pentapeptide doesn’t release the same volumes of cortisol, acetylcholine, prolactin and aldosterone. It is for this reason Ipamorelin has been considered the first selective GH-Secretagogue.

The Blend

By combining both ipamorelin and tesamorelin, it may be possible to produce enhanced effects because each peptide stimulates the growth hormone axis via two different mechanisms. Together, they both work synergistically to stimulate the pituitary gland to produce and secrete your own natural growth hormone at more youthful levels. Research has shown that the net effect of combining both of these peptides results in better deep sleep, reduced triglycerides, VAT, and cIMT, improved cognition, and overall better metabolic function.

Ipamorelin and Tesamorelin exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans.