What is Human Chorionic Gonadotropin , HCG , Pregnyl?
Human Chorionic Gonadotropin (HCG, Pregnyl) is a hormone which maintains the development of a fertilized egg in the woman. It is widely employed in the treatment of infertility. After fusion of sperm and ovum in fallopian tube the fertilized egg attaches to the uterus wall by the placenta. After implantation the cells of placenta start to secret Human Chorionic gonadotropin. Basically, it is a glycoprotein composed of 237 amino acids with a molecular mass of 25.7 kDa.
Structure
PubChem CID: 638793
Uses
The use of HCG in pregnancy.
(Pregnyl) plays an important role in the development of the foetus during pregnancy. After 9 days of fertilization when the fertilized egg attached to the uterus wall via placenta the formation of Human Chorionic Gonadotropin (Pregnyl) get starts. Human Chorionic Gonadotropin (HCG, Pregnyl) comes in blood circulation and from there some part of HCG can also pass in urine. For the pregnancy check, the levels of HCG is determined in urine. The presence of HCG confirms pregnancy. The more amount of HCG is released in case of twins and triplets in multiple pregnancy. HCG maintains the level of Progesterone which help in uterus enrichment with the thick wall of blood vessels for providing proper nutrition to the developing foetus.
The use of Pregnyl in curing infertility
Since it triggers the ovulation (release of the ovum) thus having a significant role to treat infertility in females. Along with this, it stimulates the formation of testosterone which is needed for the sperm formation in males. Hence, it has a great role in the treatment of both male and female infertility.
The use of Human Chorionic Gonadotropin (HCG) in treatment of female infertility
Pregnyl is extensively used parent rally for final maturation induction in place of luteinizing hormone. It triggers ovulation in the presence of one or more mature ovarian follicles. The release of the ovum occurs after between 38 and 40 hours after its administration that’s why with a schedule, this is given to the woman who is going for in vitro fertilization (IVF) artificial insemination.
Treatment of male infertility
In males, it stimulates the formation of testosterone by stimulating the Leydig cells. The formation of sperm from Sertoli cells essentially need Testosterone so it is is useful to treat infertility in the men having no sperm or low sperm count.
| Dosage | 5000iu x 1 vial (Pharmaceutical Grade), 5000iu x 10 vials (Generic Compound) |
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